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Evidence is increasing that addiction without exception is related to difficulty with the brain’s reward center, especially the mesolimbic system. This part of the problem regulates reward responses in acquiring food and sex, plus in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both once they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates “the quantity of dopamine released in in response to a stimulus”(Bostwick & Bucci, 2008).
Using two separate drugs to shed pounds can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight loss and the people who go through it you need to err to the side of caution and allow the FDA do its job and demand some research be done so that the public is aware of the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies have been in business to generate income and that they would say anything to keep people on their medications.
Researchers found out that participants investing in this drug for a year, lost excess weight within one month and have kept the load off throughout the 56 weeks with the study. Contrave can be a combination in the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which are made up of several active ingredient, which can make them more efficient and safer.
Combo-pilling could be the newest fad or also the newest in the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular will be the fact that by right now there are no long term prescription slimming capsules that have been authorized by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be approved by the FDA.
Seizures certainly are a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug could also raise blood pressure level and heartrate, and mustn’t be used in individuals with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug.
The FDA also warned that Contrave can raise hypertension and pulse rate and must ‘t be used in patients with uncontrolled high blood pressure level, along with by you aren’t heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients using a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert medical professionals and patients to the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking.
Acamprosate also actively works to eliminate the want to drink by reducing the the cravings for drinking alcohol. The major difference between Naltrexone and Acamprosate is the fact that Acamprosate isn’t yet accessible in the United States. While it continues to be widely studied in Europe the exact chemical reason why it works remains to be unknown. It is considered that it disrupts receptors inside the brain which process glutamate, which in essence alters just how ones body reacts to alcohol intake. Several of the European research has revealed a lot of promise with Acamprosate in this some of the patients had an almost double success rate for staying sober.